Publications

For updated publications please refer to Jonathan Little’s Google Scholar

2025/2026

 Examining the feasibility of prolonged beta-hydroxybutyrate-containing supplement drink consumption in adults with type 2 diabetes: a randomized controlled pilot trial 

90days_Ketone_JANA_MANUSCRIPT_R1_full

Effect of Acute and Chronic Ingestion of Exogenous Ketone Supplements on Blood Pressure A Systematic Review and Meta-Analysis

Acute effect of an exogenous ketone monoester supplement on appetite and food intake in adults with type 2 diabetes

Satiety paper_cleaned_27mar2024

Oliveira B, Falkenhain K,  Davy, Davy KP,  Little JP.

2023

2022

Oligofructose-Enriched Inulin Intake, Gut Microbiome Characteristics, and the V̇O₂ Peak Response to High-Intensity Interval Training in Healthy Inactive Adults

Sugar-Free Dark Chocolate Consumption Results in Lower Blood Glucose in Adults With Diabetes

Exercise Snacks: A Novel Strategy to Improve Cardiometabolic Health

H Islam, MJ Gibala, JP Little

Exercise and sport sciences reviews 50 (1), 31-37

2021

Oligofructose-enriched inulin intake, gut microbiome characteristics and the V̇O2peak response to high-intensity interval training in healthy inactive adults

Mobile Health Biometrics to Enhance Exercise and Physical Activity Adherence in Type 2 Diabetes (MOTIVATE-T2D): protocol for a feasibility randomised controlled trial

A randomized controlled trial of pharmacist-led therapeutic carbohydrate and energy restriction in type 2 diabetes

Cody Durrer, Sean McKelvey, Joel Singer, Alan M. Batterham, James D. Johnson, Kelsey Gudmundson, Jay Wortman & Jonathan P. Little

Nature Communications

14-days of ketone supplementation lowers glucose and improves vascular function in obesity: a randomized crossover trial

JJ Walsh, H Neudorf, JP Little

The Journal of Clinical Endocrinology & Metabolism

Prior ingestion of a ketone monoester supplement reduces postprandial glycemic responses in young healthy-weight individuals

Increased Cardiorespiratory Stress During Submaximal Cycling After Ketone Monoester Ingestion in Endurance-Trained Adults

2019

Pharmacist-led therapeutic carbohydrate restriction as a treatment strategy for type 2 diabetes: the Pharm-TCR randomized controlled trial protocol

C Durrer, S McKelvey, J Singer, AM Batterham, JD Johnson, J Wortman, .Trials 20 (1), 1-9

Short-term exercise training reduces glycaemic variability and lowers circulating endothelial microparticles in overweight and obese women at elevated risk of type 2 diabetes

H Rafiei, E Robinson, J Barry, ME Jung, JP Little. European journal of sport science 19 (8), 1140-1149

2018

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

Cardiovascular benefits of combined interval training and post-exercise nutrition in type 2 diabetes

ME Francois, KJ Pistawka, FA Halperin, JP Little. Journal of diabetes and its complications 32 (2), 226-233

Integrative Cardiovascular Physiology and Pathophysiology: Carbohydrate restriction with postmeal walking effectively mitigates postprandial hyperglycemia and improves …

2017

Barry JC, Simtchouk S, Durrer C, Jung ME, Little JP . Short-term exercise training alters leukocyte chemokine receptors in obese adults. Med Sci Sports Exerc. doi:10.1249/MSS.0000000000001261

Durrer C, Francois M, Neudorf H, Little JP. (2017) Acute high-intensity interval exercise reduces monocyte toll-like receptor 2 expression in type 2 diabetes. AJP-Regulatory, Integrative and Comparative Physiology. 312(4), R529.

Eaton M, Granata C, Barry J, Safdar A, Bishop DJ, Little JP. (2017). Impact of a single bout of interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA in human skeletal muscle. Journal of Sports and Health Science. doi:10.1016/j.jshs.2017.01.003

2016

Forbes SC, Sletten N, Durrer C, Myette-Cote É, Candow D, Little JP. (2016). Creatine monohydrate supplementation does not augment fitness, performance, or body bomposition adaptations in response to four weeks of high-intensity interval training in young females. Int J Sport Nutr Exerc Metab. 1-23. doi:10.1123/ijsnem.2016-0129

Francois ME, Durrer C, Pistawka K, Halperin F, Little JP (2016). Resistance-based interval exercise improves endothelial function in type 2 diabetes. American Journal of Physiology: Heart and Circulatory Physiology. 311(5), H1258-H126. doi:10.1152/ajpheart.00398.2016

Little JP, Myette-Cote E (2016). Comment on Alarcon et al. Pancreatic beta-cell adaptive plasticity in obesity increases insulin production but adversely affects secretory function. Diabetes. 65(8), E28. DOI: 10.2337/db16-0492

Barry JC, Shakibakho S, Durrer C, Simtchouk S, Jawanda KK, Cheung ST, Mui AL, Little JP. (2016) Hyporesponsiveness to the anti-inflammatory action of interleukin-10 in type 2 diabetes.Scientific Reports. 6, 21244. doi: 10.1038/srep21244

Bailey KJ, Little JP, Jung ME. (2016) Self-Monitoring Using Continuous Glucose Monitors with Real-Time Feedback Improves Exercise Adherence in Individuals with  Impaired Blood Glucose: A Pilot Study. Diabetes Technol Ther. 18(3), 185-93. doi:10.1089/dia.2015.0285

Jung ME, Little JP, Batterham A (2016). Commentary: Why sprint interval training is inappropriate for a largely sedentary population. Frontiers in Psychology. 6, 1999. doi:10.3389/fpsyg.2015.01999

2015

MacPherson RE, Baumeister P, Peppler WT, Wright DC, Little JP (2015) Reduced cortical BACE1 content with one bout of exercise is accompanied by declines in AMPK, Akt, and MAPK signaling in obese, glucose-intolerant mice. J Appl Physiol. 119(10), 1097-1104.  doi:10.1152/japplphysiol.00299.2015

Robinson E, Durrer CG, Simtchouk S, Jung ME, Bourne JE, Voth E, Little JP (2015). Short-term high-intensity interval and moderate-intensity continuous training reduce leukocyte TLR4 in inactive adults at elevated risk of type 2 diabetes. Journal of Applied Physiology. 119(5), 508-516. doi: 10.1152/japplphysiol.00334.2015

Jung ME, Bourne J, Beauchamp MR, Robinson E, Little JP (2015). High-intensity interval training as an efficacious alternative to moderate-intensity continuous training for adults with prediabetes. Journal of Diabetes Research, 2015. 1-9. doi:10.1155/2015/191595.

Durrer CG, Robinson EG, Wan Z, Martinez N, Hummel M, Jenkins NT, Kilpatrick M, Little JP (2015). Differential impact of acute high-intensity exercise on circulating endothelial microparticles and insulin resistance between overweight/obese males and females. PLOS ONE. 10(2), e0115860. doi: 10.1371/journal.pone.0115860

Martinez N, Kilpatrick MW, Salomon K, Jung ME, Little JP (2015). Affective and enjoyment responses to high-intensity interval training in overweight-to-obese and insufficiently active adults. Journal of Sport and Exercise Psychology, 37(2), 138-149. doi:10.1123/jsep.2014-0212

Wan, Z., Mah, D., Simtchouk, S., Kluftinger, A., Little JP. (2015) Role of amyloid beta in the induction of lipolysis and secretion fo adipokines from human adipose tissue. Adipocyte. 4(3), 212-216. doi: 10.4161/21623945.2014.985020.

Wan, Z., Mah, D., Simtchouk, S., Kluftinger, A., Little JP (2015). Human Adipose Tissue Conditioned Media from Lean Subjects Is Protective against H₂O₂ Induced Neurotoxicity in Human SH-SY5Y Neuronal Cells. Int. J. Mol. Sci. 16(1), 1221-1231; doi:10.3390/ijms16011221.

Francois ME, Little JP (2015). Effectiveness and safety of high-intensity interval training in patients with type 2 diabetes, Diabetes Spectrum. 28(1), 39-44. doi:10.2337/diaspect.28.1.39.

2014

Jung ME, Bourne JE, Little JP. (2014). Where does HIT Fit? An examination of the affective response to high-intensity intervals in comparison to continuous moderate- and continuous vigorous-intensity exercise in the exercise intensity/-affect continuum. PLOS ONE. 9(12), e114541. doi:10.1371/journal.pone.0114541

Kilpatrick M, Jung ME, Little JP (2014) High-intensity interval training: A review of the physiological and psychological responses. ACSM’s Health and Fitness Journal. 18(5), 11-16. doi:10.1249/FIT.0000000000000067

Little JP, Francois ME (2014). High-intensity interval training for improving postprandial hyperglycemia. Res Q Exerc Sport. 85(4), 451-6. doi:10.1080/02701367.2014.963474.

Wan, Z., Little JP. (2014). Adiponectin and Alzheimer’s disease: Is there a link? Inflammation and Cell Signaling. 1(4), e154.

Wan, Z., Durrer C, Simtchouk S, Mah D, Little JP. (2014). One week high fat diet leads to impaired toll-like receptor 2 (TLR2) expression and function in young healthy men. Nutrition Research. Nutrition Research. 34(12), 1045-1051. doi:10.1016/j.nutres.2014.08.012

Wan, Z., Durrer C, Simtchouk S, Mah D, Little JP. (2014). Reduction of AMPK activity and altered MAPKs signalling in peripheral blood mononuclear cells in response to acute glucose ingestion following a short-term high fat diet in young healthy men. Metabolism – Clinical and Experimental. 63(9), 1209-1216. doi:10.1016/j.metabol.2014.06.007

Little, J.P., Simtchouk, S., Villanueva, E.B., Gill, N.E., Walker, D.G., Wolthers, K.R., Klegeris, A. (2014). Mitochondrial transcription factor A (Tfam) is a pro-inflammatory extracellular signaling molecule recognized by brain microglia. Molecular and Cellular Neuroscience. 60, 88-96. doi: 10.1016/j.mcn.2014.04.003

Wan, Z., Mah, D., Simtchouk, S., Klegeris, A., Little, JP. (2014). Globular adiponectin induces a pro-inflammatory response in human astrocytic cells. Biochemical and Biophsycial Research Communications. 446(1), 37-42. doi:10.1016/j.bbrc.2014.02.077

Little JP, Jung ME, Wright AE, Wright W, Manders RJF (2014). Effects of high-intensity interval exercise versus continuous-moderate intensity exercise on postprandial glycemic control assessed by continuous glucose monitoring in obese adults. Applied Physiology, Nutrition, and Metabolism. 39(7), 835-841. DOI: 10.1139/apnm-2013-0512

For a full list of publications from Dr. Little on PubMed please visit:

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/48781082/?sort=date&direction=ascending